Defending champion Naomi Osaka was dumped out of the Australian Open in the third round Friday by unseeded American Amanda Anisimova to open up the draw for title favorite Ashleigh Barty.
Anisimova, ranked 60th in the world, saved two match points to stun the former world No 1 4-6, 6-3, 7-6 (10/5) and will now face Barty in the last 16.
It was a hugely disappointing end for Osaka in Melbourne, having also gone out at the same stage at the US Open in September, after which she took a break from tennis.
In the men's draw, Rafael Nadal underlined his status as one of the favorites with a four-set victory over Russian 28th seed Karen Khachanov.
But day five at Melbourne Park was all about the 20-year-old Anisimova.
Four-time Grand Slam winner Osaka attempted to find a positive, the dethroned Japanese champion saying she can't always win.
Anisimova will be eyeing another scalp in the form of Australia's Barty, who was a comfortable 6-2, 6-3 winner over Italian 30th seed Camila Giorgi, inching closer to a maiden Grand Slam crown on home soil.
Barty, 25, is now 7-0 for the season and yet to drop a set in Melbourne.
Also into round four is two-time champion Victoria Azarenka.
The 24th seed crushed 15th seed Elina Svitolina as she tries to climb back to the top of women's tennis.
The 32-year old Belarusian turned back the clock with a 6-0, 6-2 dismissal of her Ukrainian opponent and will now play French Open champion Barbora Krejcikova for a place in the quarter-finals.
Azarenka, who won back-to-back Australian Opens in 2012 and 2013, is rallying on in her efforts to get back among the elite.
Krejcikova overcame a big fright against 2017 Roland Garros winner Jelena Ostapenko.
The Czech dropped the first set and was a break down in the second before coming through 2-6, 6-4, 6-4 and declaring her never-say-die attitude meant her rivals should be afraid of her.
The 26-year-old was one of the standout players of 2021, winning three titles as she soared more than 50 places up the ranking.
Fifth seed Maria Sakkari and eighth seed Paula Badosa also went through.
In the absence of the deported defending champion Novak Djokovic and injured Roger Federer, Spanish legend Nadal is attempting to become the first man to win 21 majors.
He dropped a set for the first time at this tournament but called his 6-3, 6-2, 3-6, 6-1 win over Khachanov under the lights his best performance since he returned this year following a foot injury that ended his 2021 season early.
The 35-year-old could face Olympic champion Alexander Zverev in the quarter-finals.
World No 3 Zverev powered his way into the last 16 with a superb serving display against Moldova's Radu Albot.
The powerful Tokyo Olympic gold medallist thundered down 16 aces to put away the 124th-ranked Albot, 6-3, 6-4, 6-4.
Zverev will next take on Canada's 14th seed Denis Shapovalov.
Also through is Italian seventh seed Matteo Berrettini, who came through a five-set epic against talented Spanish 18-year old Carlos Alcaraz 6-2, 7-6 (7/3), 4-6, 2-6, 7-6 (10/5).
Flamboyant French 17th seed Gael Monfils, who won the Adelaide warm-up event, continued his great early-season form with a 7-6 (7/4), 6-1, 6-3 romp against 16th-seeded Christian Garin of Chile.
