Barcelona will face Atletico Madrid in the Copa del Rey semi-finals, while Real Madrid were pitted against Real Sociedad in Wednesday's draw.
It is the first time since 2014 that Spain's big three teams have reached the final four, with Sociedad also there on that occasion.
Record 31-time winners Barca, who last lifted the trophy in 2021, will host Diego Simeone's side in the first leg on February 25 before visiting the Metropolitano stadium on April 2.
Atletico, second in LaLiga a point ahead of the Catalan giants, last lifted the trophy in 2013 and have won it on 10 occasions.
Spanish and European champions Real, 20-time cup winners, visit San Sebastian in the first leg on February 26 before hosting Sociedad in the return on April 1.
Basque side Sociedad have only won the trophy twice, most recently claiming the 2020 edition.
