Holders Manchester City were handed a tie against FC Copenhagen in Monday's draw for the Champions League last 16, from which the meeting of last season's runners-up Inter Milan and Atletico Madrid appears the standout tie.
Inter, the Serie A leaders, were one of the teams to avoid after finishing second in their group and the meeting with Atletico will see Diego Simeone, the coach of the Spanish club, come up against a team with whom he spent two years as a player in the late 1990s.
French champions Paris Saint-Germain, who have gone out in the last 16 in each of the last two seasons and in five of the last seven campaigns, were also braced for a tough draw having come second in their group behind Borussia Dortmund.
They will therefore be relieved at being handed a tie against Real Sociedad, who topped their section above Inter but are appearing in the Champions League last 16 for the first time since 2003/04, when they were knocked out by Lyon.
Barcelona's meeting with Italian champions Napoli is another standout tie, while Premier League leaders Arsenal will be expected to get the better of Porto and reach the quarter-finals for the first time since 2010.
This season's Champions League final will be staged at Wembley in London on June 1.
We take a look at each tie after Monday's draw for the last 16 of this season's UEFA Champions League:
Arsenal v Porto
Arsenal will be favorites, although Porto have made the last eight three times since then. Mikel Arteta's Gunners are playing in the competition for the first time since suffering a seventh straight last-16 exit under Arsene Wenger in 2017. Porto beat Shakhtar Donetsk 5-3 in their final group game to go through, with 40-year old defender Pepe extending his record as the oldest Champions League goalscorer.
Barcelona v Napoli
It will be the third meeting in five seasons of these clubs, two of the late Diego Maradona's former teams. Barca won 4-2 on aggregate in the last 16 of the 2019/20 edition, and they also came out on top in the knockout round play-offs of the Europa League two years ago. Barca topped their group ahead of Porto thanks to a superior head-to-head record, but lost away to both Shakhtar and Royal Antwerp. Napoli appear not quite the same force as last season, when they claimed a first Serie A title in 33 years, and came second to Real Madrid in their group after losing twice against the Spaniards.
Sociedad v PSG
The French champions will be hopeful now of advancing to the quarter-finals as they continue their quest to win a first Champions League crown, in what could be their last chance to lift the trophy with Kylian Mbappe as his contract expires in six months. Sociedad look dangerous though. They have only been beaten this season by Real, Atletico and Barca.
Atletico v Inter
This is the standout tie, with last season's beaten finalists Inter currently top of Serie A while Atletico are on the fringes of the title race in LaLiga and topped their Champions League group without losing. Simeone this month celebrates 12 years in charge of the club. The first leg will also see Atletico return to San Siro, scene of their defeat on penalties by Real Madrid in the 2016 final.
Dortmund v PSV
Winners of their first 16 Eredivisie games, PSV are a victory away from equalling the best-ever start to a Dutch season, a record they set in 1987-88 - a campaign which ended with the club's lone European Cup triumph. PSV boss Peter Bosz will come up against the side who sacked him in 2017 after five months in charge. Inconsistent in Germany this term, Dortmund have produced their best work on the continent, topping a challenging Group F ahead of PSG, AC Milan and Newcastle United.
Bayern v Lazio
Mired in the bottom half of Serie A, Lazio meet the same team they faced on their most recent appearance in the last 16 three years ago. Goalkeeper Ivan Provedel delivered one of the standout moments of this season's competition with his stoppage-time equalizer on matchday one against Atletico. Bayern once again sailed through the group stage and will be relying on the goals of Harry Kane - who has scored 24 times in 21 matches - in their quest for a seventh European crown.
Man City v Copenhagen
Copenhagen had to come through three two-legged rounds of qualifying to reach the group stage, before home wins over Manchester United and Galatasaray fired them into the last 16 for the first time in 13 years. The Danes will be massive underdogs against holders City, although Pep Guardiola's men have struggled at times this season, winning just one of their last six Premier League matches to fall five points behind leaders Arsenal.
Real Madrid v Leipzig
Record 14-time European champions Real suffered six successive exits from the competition in the last 16 between 2005 and 2010. Since then, however, they have only gone out in the first knockout round on two occasions. Coach Carlo Ancelotti is having to deal with an injury crisis this season but they must still be considered one of the favorites to go all the way, especially given Jude Bellingham's form. Leipzig, currently third in the Bundesliga, came second in their group behind City. They were eliminated by City at this stage last season, losing 8-1 on aggregate. That was after they faced Real in the group stage, losing in Spain but winning 3-2 at home.
LAST 16 DATES
1st leg: Feb 13-14 and 20-21
2nd leg: March 5-6 and 12-13
Seeded teams (named 1st) will play the 2nd leg at home
