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Dhaka Tribune

Grapes interact badly with many drugs

Update : 30 May 2014, 06:41 PM

Grapefruit is the one of the common fruits, which we see on patients’ sidetables in hospitals and homes. All patients have to take medicines for their chronic or acute illnesses. Patients usually take grapefruits to combat the weakness due to illness. But the bad news is that a research published recently in a issue of the Canadian Medical Association Journal showed, many of the common drugs interact with grapefruit.  Of the 85 known drugs that interact with grapefruit, 43 can have serious side effects, including sudden death, acute kidney failure, respiratory failure, gastrointestinal bleeding, and bone marrow suppression in people with weakened immune systems.

People older than 45 are more likely to face these interactions, compared  to the young and middle-aged. The researchers also noted that all sources of grapefruit — the whole fruit or 200 ml of grapefruit juice — and other citrus fruit such as oranges (often used in marmalade), limes and pomelos can lead to drug interactions.

Some cholesterol-lowering statins, antibiotics and calcium channel blockers used to treat high blood pressure, few agents used to fight cancer or suppress the immune system in people who have received an organ transplant, are the common medicines which interact with grapefruits.

Researchers advised to not take those drugs with these fruits. The interaction can occur even if someone eats grapefruit or drinks the juice hours before taking a drug, such as drinking the grapefruit juice at breakfast and taking the medication after dinner.


Drugs that interact with grapefruit

Anti-cancer : Crizotinib, Dasatinib, Erlotinib, Everolimus, Lapatinib, Nilotinib, Pazopanib, Sunitinib, Vandetanib, Venurafenib.

Anti-infective: Erythromycin, Halofantrine, Maraviroc, Primaquine, Quinine, Rilpivirine.

Anti-cholesterol: Atorvastatin, Lovastatin, Simvastatin.

Cardiovascular: Amiodarone, Apixaban, Clopidogrel, Dronedarone, Eplerenone, Felodipine, Nifedipine, Quinidine, Rivaroxaban, Ticagrelor.

Central nervous system:  Alfentanil (oral), Buspirone, Dextromethorphan, Fentanyl (oral), Ketamine (oral), Lurasidone, Oxycodone, Pimozide, Quetiapine, Triazolam, Ziprasidone.

Gastrointestinal: Domperidone.

Immunosuppressants: Cyclosporine, Everoli.

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