Four more Covid-19 patients and patients with symptoms died at Rajshahi Medical College and Hospital (RMCH) in the 24 hours to 8am on Saturday, said hospital officials.
One of the deceased, a resident of Chapainawabganj, tested positive for the deadly virus, said RMCH Deputy Director Saiful Ferdous.
Three others with symptoms of the disease hailed from Rajshahi, he added.
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As many as 289 patients were undergoing treatment at Covid-19 unit of the hospital until Saturday morning, with 25 people got admitted over the last 24 hours.
There are 271 beds at the hospital's Covid unit.
With the latest fatalities, a total of 161 people have died at the Covid unit of RMCH since May 24, said Dr Ferdous.
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Eighty-four of the deceased contracted Covid-19, he added.
In light of the worsening coronavirus situation in the division, the local authorities enforced an all-out week-long lockdown from 5pm on Friday in Rajshahi metropolitan city.