Ruud van Nistelrooy enjoyed a winning start as interim Manchester United manager by beating Leicester City 5-2 to reach the League Cup quarter-finals Wednesday as Manchester City crashed out 2-1 to Tottenham Hotspur.
Arsenal and Liverpool were among the other sides to book their place in the last eight, but Chelsea were beaten 2-0 at Newcastle United.
A United legend as a player, Van Nistelrooy was thrust into the role of interim manager after the Red Devils sacked Erik ten Hag Monday following a dreadful start to the season.
Sporting Lisbon boss Ruben Amorim is the man the English giants have targeted to take over but are still in negotiations with the Portuguese champions to agree compensation for the 39-year old.
According to reports in Portugal, Amorim will remain at Sporting for the next three matches before completing his move during the November international break.
Van Nistelrooy said before the game that United "can be unstoppable" when "players, staff and supporters pull together" and they cut loose by scoring four times in a thrilling first 45 minutes.
Casemiro's stunning effort into the top corner opened the scoring before Alejandro Garnacho swept home Diogo Dalot's cross to please a jubilant Van Nistelrooy on the touchline.
Bilal El Khannouss quickly pulled a goal back for the much-changed Foxes.
Bruno Fernandes' deflected free-kick restored United's two-goal cushion before Casemiro slammed home his third goal in two games.
Conor Coady grabbed another consolation for Leicester but United were not to be denied just a second win in nine games.
Fernandes rounded off the scoring when he pounced on a short back-pass to round Danny Ward and fire home.
City paid for leaving Erling Haaland out in north London as Tottenham moved a step closer to ending their 16-year trophy drought.
Timo Werner slotted home his first goal since March from Dejan Kulusevski's inviting cross.
Pape Sarr's long-range strike doubled Spurs' lead before Matheus Nunes got City back into the tie in first-half stoppage time.
But they could not find an equalizer and Pep Guardiola showed where his priorities lie as Haaland remained on the bench for the full 90 minutes.
Cody Gakpo was the match-winner for Liverpool in a 3-2 win at Brighton and Hove Albion to continue Arne Slot's excellent start to life with the Reds.
Gakpo has not scored in the Premier League or Champions League this season but now has four goals in two League Cup games.
The Dutch international was ruthless with two powerful finishes cutting inside onto his right foot from the left wing.
Luis Diaz was also on target for Liverpool, while Simon Adingra and Tariq Lamptey struck late on for Brighton.
Teenager Ethan Nwaneri caught the eye with a sensational strike as Arsenal eased to a 3-0 win at Championship side Preston North End.
Gabriel Jesus and Kai Havertz got the other goals for the Gunners.
Newcastle gained revenge for their Premier League defeat at Chelsea at the weekend to ease the pressure on manager Eddie Howe.
The Saudi-backed Magpies are winless in five in the league, but are desperate to end a 55-year wait to win a major trophy.
Alexander Isak's strike and an Axel Disasi own goal inside three first-half minutes proved decisive at St. James' Park.
Crystal Palace backed up their first Premier League win of the season Sunday by beating Aston Villa 2-1 thanks to goals from Eberechi Eze and Daichi Kamada.
4TH ROUND RESULTS
Brighton 2 (Adingra 81, Lamptey 90) Liverpool 3 (Gakpo 46, 63, Diaz 85)
Villa 1 (Duran 23) Palace 2 (Eze 8, Kamada 64)
Man Utd 5 (Casemiro 15, 39, Garnacho 28, Fernandes 36, 59) Leicester 2 (El Khannouss 33, Coady 45+3)
Newcastle 2 (Isak 23, Disasi 26-og) Chelsea 0
Preston 0 Arsenal 3 (Jesus 24, Nwaneri 33, Havertz 57)
Tottenham 2 (Werner 5, Sarr 25) Man City 1 (Nunes 45+4)
Tuesday
Southampton 3 (Harwood-Bellis 19, Armstrong 35-P, Bree 88) Stoke 2 (Phillips 45, Cannon 54)
Brentford 1 (Schade 11) Sheffield Wednesday 1 (Gassama 57)
Brentford won 5-4 on penalties
