Aston Villa beat champions Manchester City Wednesday to extend their remarkable winning run at home as Liverpool closed to within two points of leaders Arsenal with victory at Sheffield United.
Elsewhere on a busy program in the English top flight, Scott McTominay scored twice as Manchester United beat Chelsea 2-1 and Fulham hammered Nottingham Forest 5-0, heaping the pressure on manager Steve Cooper.
Villa, who have now won 14 league games in a row at home, scored the only goal of the game in the 74th minute, when Leon Bailey's shot took a huge deflection off Ruben Dias.
Pep Guardiola's men, aiming for an unprecedented fourth consecutive top-flight title, are now winless in four games and five points behind leaders Arsenal.
Last year's treble winners, missing the suspended Rodri, have now won just three league games in nine.
Liverpool, looking increasingly dangerous, saw off basement club Sheffield 2-0.
Virgil van Dijk scored opened the scoring at Bramall Lane, turning home a Trent Alexander-Arnold corner in the 37th minute from near the penalty spot.
The visitors dominated possession but failed to break through again until midfielder Dominik Szoboszlai made the points safe in time added on.
The victory takes Jurgen Klopp's team to 34 points - just two behind Arsenal, who beat Luton Town 4-3 Tuesday.
"Obviously you have to work for every game, especially against a team who changed manager," Van Dijk told the BBC.
"It was always going to a battle but we did well and deserved the three points."
It was a miserable first game back in charge for manager Chris Wilder, who returned to the club Tuesday following Paul Heckingbottom's dismissal - the first sacking of the season.
Sheffield have been defeated 12 times in 15 games and are four points from safety.
Marcus Rashford paid for his slump in form as the United star was dropped to the bench by Erik ten Hag for the match against Chelsea at Old Trafford.
But in his absence United secured a priceless three points, shrugging off a rare penalty miss from Bruno Fernandes in the first half.
Chelsea's Cole Palmer finished an impressive team move on the stroke of half-time to cancel out McTominay's opener.
But the Scotland international headed home Alejandro Garnacho's cross for his second with about 20 minutes to lift to United to sixth in the table, just three points behind City.
Mauricio Pochettino's Chelsea have now lost six games this season and are stuck in mid-table.
Forest, in their second season back in the Premier League, slumped to a fourth straight defeat at Fulham.
Alex Iwobi and Raul Jimenez scored two goals apiece and Tom Cairney completed the humiliation in the final minutes.
Brighton and Hove Albion recorded a 2-1 home win against Brentford courtesy of goals from Pascal Gross and Jack Hinshelwood.
Bournemouth notched their third win in four games, with Marcos Senesi and Kieffer Moore on the scoresheet at Palace.
Wolverhampton Wanderers beat Burnley 1-0 Tuesday.
Thursday, Everton host Newcastle United while West Ham United travel to Tottenham Hotspur.
RESULTS
Brighton 2 (Gross 31, Hinshelwood 52) Brentford 1 (Mbeumo 27-P)
Palace 0 Bournemouth 2 (Senesi 25, Moore 90+1)
Fulham 5 (Iwobi 30, 73, Jimenez 34, 54, Cairney 86) Forest 0
Sheffield Utd 0 Liverpool 2 (Van Dijk 37, Szoboszlai 90+4)
Villa 1 (Bailey 74) Man City 0
Man Utd 2 (McTominay 19, 69) Chelsea 1 (Palmer 45)
