Middle-order batter Afif Hossain and medium pacer Shoriful Islam were axed from the third and final one-day International against visiting Ireland, which will be held Thursday at Sylhet International Cricket Stadium.
The duo will now head to Dhaka to play the Dhaka Premier League for their respective sides.
The home team were trimmed to 14 from 16 after these two players were left out.
Bangladesh lead the series 1-0 following their 183-run in the first ODI, which is their largest ever victory by runs in this format.
The second ODI was washed out after Bangladesh compiled their highest ever ODI total of 349/6, thanks to a blistering 60-ball 100 not out from Mushfiqur Rahim.
In doing so, Mushfiq hit the fastest ODI ton by a Bangladeshi, eclipsing Shakib al Hasan's 63-ball century against Zimbabwe in 2009.
Following his poor form, Afif was dropped for the first time from the best XI prior to the third ODI against England.
Later he couldn't make his way to the first two ODIs against Ireland also.
His absence mattered little as Bangladesh posted their two best totals in history in these two matches.
Meanwhile, all-rounder Mehedi Hasan Miraz recovered from the eye injury which he sustained during the team's football playing session ahead of the first ODI.
He is now available for selection in the third match.
Bangladesh team for third ODI: Tamim Iqbal (captain), Liton Das, Nazmul Hossain Shanto, Shakib al Hasan, Towhid Hridoy, Mushfiqur Rahim, Yasir Ali Rabbi, Taskin Ahmed, Mustafizur Rahman, Hasan Mahmud, Nasum Ahmed, Ebadot Hossain, Rony Talukdar and Mehedi Hasan Miraz
