It is time to be anti-antibiotics

“Antibiotics are the cornerstone of modern medicine, but their misuse threatens to undermine the very foundation of our health.” 

This cautionary insight from Dr Margaret Chan, former Director-General of the World Health Organization, resonates strongly in the urban landscape of Bangladesh. The escalating misuse of antibiotics is converting this insight into a prophecy of doomsday for everyone. 

Jamal is a pharmacy worker whose familiarity with medicines garnered from his work has inadvertently transformed him into a self-appointed family medic. Lacking a formal medical background, he routinely prescribed antibiotics for himself and his family, with apparent success in achieving quick recoveries. Trusted by his family members, the pattern of antibiotic use persists whenever a fever or an upset stomach strikes.

However, a recent unsettling development shook this reliance. Despite completing a full course of antibiotics, Jamal's daughter remained unwell. A visit to the doctor revealed a troubling diagnosis -- antimicrobial resistance (AMR), a consequence of the consistent overuse of antibiotics. 

The doctor issues a stark warning: If this widespread misuse continues unchecked, a grim future awaits, where microbial infections may lead to fatalities. This scenario is not isolated; it mirrors a concerning trend permeating the urban fabric of Bangladesh. 

Antibiotic abuse is a serious problem, paving the road for antimicrobial resistance. This dangerous situation is made worse by overuse and incorrect prescription, turning once-effective antibiotics useless. As a result, common infections become more difficult to treat, resulting in longer illnesses, higher healthcare expenses, and, most concerningly, an increased risk of mortality. 

The rise of drug-resistant strains jeopardizes global public health, emphasizing the critical need for responsible antibiotic usage and strong antimicrobial resistance control efforts.

In the eleventh hour of an impending health crisis, the pressing question echoes: Why does antibiotic misuse persist, particularly among Bangladesh's urban population? 

Unraveling the origins of this pervasive issue is paramount as we stand on the brink of a health emergency. The urgency of the hour demands a meticulous exploration of the sources driving antibiotic misuse, compelling us to decipher the roots of the problem and, more crucially, to embark on swift and decisive actions to rectify this perilous trend. The time has come to unveil the intricacies and confront the challenge head-on before the looming health emergency becomes an irreversible catastrophe.

In urban Bangladesh, the misuse of antibiotics has unfortunately become a common practice rather than an exception among the general population. Many people, driven by a desire for quick relief, often engage in self-medication, getting antibiotics without a prescription. 

The issue extends to common households where there is a substantial lack of awareness about antibiotics as a distinct class or type of medicine. Shockingly, a study found that almost 97.5% of the people in Bangladesh have never even heard of the term "antibiotic resistance."

A notable misconception prevalent in some communities is the belief that antibiotics function like a vaccine. This lack of awareness and the resulting self-medication with antibiotics are significant contributors to the growth of antimicrobial resistance.

The prevalence of self-medication in Bangladesh is attributed to the easy access to antibiotics and poor regulatory controls over these drugs. In this regard, a World Bank study conducted in 2017 across six developing nations, including Bangladesh, revealed that over 60% of pharmacy visits ended with the dispensing of antimicrobials without a proper prescription.

Compounding the issue is the common sight of households with a stockpile of antibiotics obtained without proper medical consultation. Fever, a common symptom of various illnesses, often triggers individuals to take antibiotics indiscriminately, assuming they serve as a cure-all remedy. Unfortunately, this misuse is significantly contributing to the emergence of drug-resistant strains of bacteria. 

The misuse of antibiotics is not confined to the general public; medical practitioners themselves contribute to the crisis. Healthcare providers (HCPs) in Bangladesh exhibit complex prescribing behaviours marked by polypharmacy, high use of antimicrobials, and a near absence of generic prescribing. 

In some instances, doctors prescribe antibiotics unnecessarily, influenced by patient demands or diagnostic uncertainties. The pressure to provide immediate relief often results in the prescription of broad-spectrum antibiotics, exacerbating the problem of antibiotic resistance. 

Shockingly, an estimated 63% of antibiotic prescriptions nationally come from unqualified providers, with antibiotics being prescribed in almost half (44%) of all primary healthcare consultations.

The consequences of overprescribing antibiotics are noteworthy, including an increased risk of adverse effects, more frequent re-attendance, and the unnecessary medicalization of self-limiting conditions. 

A particularly alarming trend is the tendency to prescribe antibiotics for viral infections, despite their lack of efficacy against such illnesses. Some doctors, despite being well aware of the viral nature of some infections, succumb to patient expectations and prescribe antibiotics. 

This has become an unfortunate trend at present as the surge of dengue has gripped urban Bangladesh in recent times, presenting a grave health crisis. Disturbingly, a persistent misconception prevails -- a belief that antibiotics can combat dengue fever. 

While antibiotics may be employed in dengue cases to prevent secondary infections, the actual incidence of bacterial co-infection in dengue appears to be low, according to health experts. A comprehensive review of antibiotic use in malaria and dengue reveals a staggering variation in the proportion of antibiotic prescriptions, particularly in dengue cases.

Public health experts are emphasizing the critical need for accurate diagnosis and targeted treatment when dealing with viral infections. The reckless misuse of antibiotics in cases of dengue not only jeopardizes individual patient well-being but also adds fuel to the ominous fire of antibiotic resistance. 

This jeopardizes our collective ability to effectively combat bacterial infections, sounding a dire warning for the broader implications of this hazardous practice. The urgency to rectify this perilous situation cannot be overstated.

Addressing the issue of antimicrobial resistance requires a comprehensive approach involving both individuals and the healthcare system. Public awareness campaigns must be intensified to educate the population about the proper use of antibiotics and the dangers of self-medication. 

Simultaneously, healthcare providers should adhere strictly to antibiotic prescribing guidelines, emphasizing evidence-based practices and steering clear of unnecessary antibiotic prescriptions.

Moreover, regulatory measures can play a crucial role in curbing antibiotic misuse. Strict enforcement of prescription requirements for antibiotics, coupled with penalties for unauthorized sales, can act as deterrents. 

Continuous medical education programs for practitioners can also ensure that they stay abreast of the latest guidelines and maintain a judicious approach to antibiotic prescription.

The rising tide of antimicrobial resistance in urban Bangladesh is a multifaceted challenge that demands immediate attention. Addressing this crisis necessitates a collaborative effort, involving individuals, healthcare professionals, and policymakers. 

By fostering awareness, implementing stringent regulations, and promoting responsible antibiotic use, we can hope to stem the tide of resistance and safeguard the effectiveness of antibiotics for future generations. The time to act is now, before the consequences of unchecked antibiotic misuse become insurmountable.

 

Fatima Tuz Zahra is Research Assistant, Eminence Associates for Social Development. Dr Md Shamim Hayder Talukder is CEO, Eminence Associates for Social Development.