An Airbus A320 plane operated by Germanwings crashed Tuesday in southeastern France near Digne les Bains, reported a number of International news outlets.
Quoting French Prime Minister Manuel Valls, news outlets said the plane was headed from Barcelona, Spain, to Dusseldorf, Germany.
Valls said he feared those aboard -- 142 passengers and six crew members -- may be dead.
French president Francois Hollande said: "It’s a tragedy on our soil.”
In a live briefing Tuesday, Hollande said the area of the crash was remote and it was not clear whether anyone on the ground had been hurt.
He said he would soon speak to German Chancellor Angela Merkel as it was probable that a number of the victims are German.
Germanwings, the airline apparently involved, has not yet confirmed any crash, saying in a statement on Twitter that it still did not have any confirmed information.
Flight Radar has said the flight was from Barcelona to Dusseldorf with the plane losing signal around 40 minutes after it departed.
Low cost airline Germanwings is a subsidiary of Lufthansa, the largest airline in Europe. This was the first crash by a civil airliner in France since 2000, when Concorde crashed near Paris.