The religious leaders from Christian, Jewish and Muslims across the world have called for an end to the recent spate of violence in the name of religion.
They made the joint appeal in a media release.
The religious leaders said they were concerned about the ultimatum to the Christians to leave the town of Mosul.
"We have also heard about the desecration of Christian holy spaces and their symbols," they said.
They also termed those actions an appalling blot on the proud tradition of pluralism in a region which has been home to Chaldeans, Assyrians and other Churches of the East for more than 1,700 years.
"The destruction caused by the violence has engulfed all of the diverse populations in Iraq who have been uprooted from the region in fear of their lives," said the religious leaders.
They also expressed concern over the ongoing situation in Gaza and Israel.
They appeal to the leaders and brokers of power in Mosul and around the world that the holy spaces should not devolve into venues that separate us from each other.
"Instead, they [leaders] should be venues for dialogue and for conversation, so that we may recognise the values of human dignity and solidarity to which we all subscribe. Only by having these shared conversations, we will be able to better understand each other."