Three-time US Open champion Nadal advanced without striking a ball when injury-plagued Australian Thanasi Kokkinakis pulled out of their scheduled evening tie on Arthur Ashe with a right shoulder problem
Fifteen-year-old American sensation Coco Gauff set up an eye-catching US Open showdown with defending champion Naomi Osaka while Rafael Nadal's path to the title eased further Thursday as he received a walkover into the third round.
Reigning Wimbledon champion Simona Halep, meanwhile, crashed out early in New York for a third year running, blowing a match point in a tense three-set loss to 116th-ranked Taylor Townsend.
Gauff, who made a remarkable run to the fourth round at Wimbledon before falling to Halep, defeated Hungarian qualifier Timea Babos 6-2, 4-6, 6-4 to become the youngest player in the last 32 at a US Open since Anna Kournikova in 1996.
"It has been amazing. I'm just so happy to get through," Gauff said as chants of her name rang out around Louis Armstrong Stadium.
"I had to dig really deep today. I'm just proud of the way I fought and I'm glad it was all worth it in the end."
Asked about her impending clash with world number one Osaka, Gauff said her primary focus was on Friday's doubles match with 17-year-old partner Caty McNally.
"Saturday, I'm going to think about the match, but tomorrow (Friday) I'm worried about my doubles match," she said.
Three-time US Open champion Nadal advanced without striking a ball when injury-plagued Australian Thanasi Kokkinakis pulled out of their scheduled evening tie on Arthur Ashe with a right shoulder problem.
The Spanish 18-time Grand Slam winner will meet South Korean qualifier Chung Hyeon for a spot in the last 16.
His path to a fourth title, already helped with "Big Three" rivals Novak Djokovic and Roger Federer on the opposite side of the draw, cleared further having already seen four top-10 rivals dumped out in the first round.
Schedule update:— US Open Tennis (@usopen) August 29, 2019
Thanasi Kokkinakis has withdrawn from the US Open and Nadal will advance via walkover.
The Cilic/Stebe match has been moved to the 2nd night match in Arthur Ashe Stadium.
📖: https://t.co/VDHOwg5t2j pic.twitter.com/qkmqeFKc4p
Alexander Zverev, the sixth seed, is the highest-ranked player remaining on his side of the draw, as the German survived a second successive five-set marathon by outlasting American Frances Tiafoe 6-3, 3-6, 6-2, 2-6, 6-3 to equal his best US Open run.
Townsend upended women's fourth seed Halep 2-6, 6-3, 7-6 (7/4), the Romanian consigned to another premature exit at Flushing Meadows, having been knocked out in the opening round in 2017 and 2018.
"I was not inspired at all today, but I fought. I thought when I came back that I will take it and I will win it. But sometimes it goes the other way," Halep said.
Townsend recovered from wasting two match points to then save one and force a tie-break she dominated to claim her first win over a top-10 player.
"This means a lot. It has been a long journey," said a tearful Townsend, who matched her run to the French Open third round on her Grand Slam debut in 2014.
Top seed Osaka proved too strong for 53rd-ranked Magda Linette of Poland, sweeping to a 6-2, 6-4 victory.
"I feel like I had my moments where I played really well," Osaka said. "I think the main thing for me was that I was able to adjust whenever I figured out something was going wrong, so I think I'm heading in the right direction."
Among the celebrities watching her match at Louis Armstrong Stadium were basketball legend Kobe Bryant and former NFL quarterback Colin Kaepernick, whose kneeling protest became a national symbol for champions of social justice and racial equality.
"I'm really grateful they came out," Osaka said. "It's really cool. I honestly just wanted to finish as fast as possible because I didn't want them to be out in the sun too long."
Men's fifth seed Daniil Medvedev, coming off a maiden Masters title in Cincinnati, was struck down by cramp during a 6-3, 7-5, 5-7, 6-3 win over Bolivia's Hugo Dellien.
"I'm not sure what happened today and why I started cramping suddenly," Medvedev said. "I obviously thought at one point 'How did I win?' I don't know how I did."
Stan Wawrinka, the 2016 US Open champion, beat Jeremy Chardy in four sets and is on a fourth-round collision course with Djokovic, while Australian 28th seed Nick Kyrgios rolled past 104th-ranked French wildcard Antoine Hoang 6-4, 6-2, 6-4.
Andrea Petkovic knocked out Czech sixth seed Petra Kvitova 6-4, 6-4, while 15th seed Bianca Andreescu and two-time runner-up Caroline Wozniacki also progressed.