Defending champion and world number one Andy Murray was swept aside by home favourite Fabio Fognini at the Italian Open on Tuesday, being completely outplayed in a 6-2 6-4 defeat.
Only a late spell of resistance when he reeled off three games at 1-5 in the second set kept the scoreline respectable as the British player's worrying slump in form continued ahead of this month's French Open.
An inspired Fognini, whose wife former U.S. Open champion Flavia Pennetta is expecting their first child this week, thumped 31 winners in his first victory over a world number one.
Murray has won only five of his last 10 matches but while he continues to search for some spark in a lacklustre claycourt season, Novak Djokovic, the man he usurped as world number one last November, is finding his just in time for Roland Garros.
The Serb built on last week's encouraging showing in Madrid to beat qualifier Aljaz Bedene 7-6 (2) 6-2 in his opening match.
Djokovic has struggled for form this year and recently split with his entire coaching staff but his game looked in good order against Bedene on Court Centrale in Rome.
He was pushed hard in the opening set by 55th-ranked Bedene and had to recover an early service break but he stepped on the gas in the second set to cruise through to the third round.
There were also wins for sixth seed Marin Cilic against American Ryan Harrison and ninth seed David Goffin, who came from a set down to beat Spain's Fernando Verdasco.
David Ferrer won an all-Spanish clash with Feliciano Lopez for his 700th career win.
Australian Nick Kyrgios withdrew with a hip injury.
On Wednesday tournament favourite Rafael Nadal takes on Spain's Nicolas Almagro while third seed Stanislas Wawrinka faces unpredictable Frenchman Benoit Paire having lost to him last week on the clay in Madrid.
ROUND 2 RESULTS
(Italy) beat Andy Murray
(Britain) 6-2 6-4
(Croatia) beat Ryan Harrison
(U.S.) 6-3 6-2
(Serbia) beat Aljaz Bedene
(Britain) 7-6 (2) 6-2
(Czech Republic) beat Carlos Berlocq
(Argentina) 6-3 6-4
(U.S.) beat Florian Mayer
(Germany) 7-6 (4) 7-6 (4)
(Belgium) beat Fernando Verdasco
(Spain) 3-6 6-3 6-2