The hosts struck early through a fantastic goal from Mertens, as the Napoli winger pounced after some slack Dutch defending, curling the ball past goalkeeper Jasper Cillessen and two men on the line, and into the top corner
The Netherlands continued their resurgence under Ronald Koeman as youngster Arnaut Groeneveld's first international goal secured a 1-1 friendly draw with Belgium in Brussels on Tuesday.
Dries Mertens fired the World Cup semi-finalists into a sixth-minute lead, but Groeneveld marked his full debut for the Dutch by equalising before the half-hour mark.
This was another strong performance for the Oranje after Saturday's stunning 3-0 Nations League victory over Germany, while Roberto Martinez's Belgium remain unbeaten at home since a loss to Spain in September 2016.
"I think there is still a lot of work to do, but we've shown that we've made good progress lately and at the end of the match we tried to play more offensively to try to win," said Koeman.
"We had the best chances and overall we can be very happy with the last 10 days."
The hosts struck early through a fantastic goal from Mertens, as the Napoli winger pounced after some slack Dutch defending, curling the ball past goalkeeper Jasper Cillessen and two men on the line, and into the top corner.
The 31-year-old continued to run the visitors ragged, stretching to dig out an excellent cross which Romelu Lukaku could only head over from less than six yards out.
The Netherlands almost levelled after a quick counter-attack, but Memphis Depay failed to get a clean connection on his shot and was denied by the legs of Simon Mignolet, making his first appearance in the Belgian goal since March.
International Friendly - RESULT:— SuperSport (@SuperSportTV) October 16, 2018
Belgium 🇧🇪 1-1 🇳🇱 Netherlands
Dries Mertens scored for Belgium while Arnaut Groeneveld netted for the Dutch as they played out to a draw pic.twitter.com/vOHrkoB9Iu
But the Lyon forward cut open the home defence in the 27th minute, sending through a perfect pass for Nigerian-born winger Groeneveld to slide home on just his second international appearance after coming on as a substitute against Germany.
The visitors continued to slice through the Belgium defence with ease, and Quincy Promes saw a fierce long-range strike bounce back off the post with Mignolet scrambling.
Eden Hazard, who has already scored 10 goals this season for club and country, should have restored the Belgian advantage before half-time, but shot wide with the goal gaping after Lukaku's clever lay-off.
Martinez rang the changes at the break, bringing on Michy Batshuayi for Lukaku and Dennis Praet for Mertens, while Thorgan Hazard replaced his older brother.
Belgium vs Netherlands 1-1 highlights HD pic.twitter.com/3namqLj6e1— socialfooty (@socialfooty_) October 16, 2018
Batshuayi twice almost scored early in the second period, shooting narrowly wide and seeing a twisting header clutched by a diving Cillessen.
The striker, on loan at Valencia from Chelsea, went close to a winner again late on, as Barcelona 'keeper Cillessen palmed away his close-range volley.