Arsenal will have another chance to beat Bayern Munich in a Champions League knockout tie after the sides were paired yet again in the round of 16 following Monday's draw.
The teams met at the same stage in 2005, 2013 and 2014 with the German champions winning on all three occasions - 3-2 on aggregate in 2005, on away goals after a 3-3 draw in 2013 and 3-1 in 2014.
Paris St Germain will also try to break a jinx when they face Spanish champions Barcelona, who knocked them out in the quarter-finals in 2013 and 2014.
Holders Real Madrid, who like Bayern finished as runners-up in their group and will therefore play the first leg at home, were given a tricky clash with Serie A side Napoli.
The draw also produced a potential grudge match as it pitted Bayer Leverkusen against Atletico Madrid, whose respective coaches Roger Schmidt and Diego Simeone were involved in an ugly touchline spat when the sides met two seasons ago.
On that occasion, Atletico went through on penalties after a 1-1 aggregate draw.
Arsenal may feel this could be their best chance to beat Bayern, whose domestic and European form has not been as dominant as in recent seasons.
Serie A champions Juventus were drawn against Porto in a repeat of the 1984 European Cup Winners' Cup final which the Italian side won 2-1.
Sevilla and English champions Leicester City will meet for the first time as will Manchester City and AS Monaco.
Benfica and Borussia Dortmund will renew their rivalry after a 52-year wait, the sides having previously met in the 1963-64 European Cup.
The first legs will be played on February 14, 15, 21 and 22 with the second legs on March 7, 8, 14 and 15.
Draw for the last 16 of the UEFA Champions League
Manchester City (ENG) v Monaco (FRA)
Real Madrid (ESP) v Napoli (ITA)
Benfica (POR) v Borussia Dortmund (GER)
Bayern Munich (GER) v Arsenal (ENG)
FC Porto (POR) v Juventus (ITA)
Bayer Leverkusen (GER) v Atletico Madrid (ESP)
Paris Saint-Germain (FRA) v Barcelona (ESP)
Sevilla (ESP) v Leicester City (ENG)
- First legs to be played on February 14/15/21/22, second legs on March 7/8/14/15