Gazzetta dello Sport and Corriere dello Sport had reported before the game that Carlo Ancelotti was set to be fired whatever the result and replaced by former AC Milan coach Gennaro Gattuso
Napoli ended a nine-match winless run in all competition to reach the Champions League last 16 Tuesday as a first-half Arkadiusz Milik hat-trick set up a 4-0 win over Genk in what eventually turned out to be coach Carlo Ancelotti's last stand.
"Napoli have decided to relieve Ancelotti of his role as first team coach," the Italian side said in a statement.
"The relationship of friendship, esteem and mutual respect between the club, its president Aurelio de Laurentiis and Ancelotti remain intact."
Gazzetta dello Sport and Corriere dello Sport had reported before the game that Ancelotti was set to be fired whatever the result and replaced by former AC Milan coach Gennaro Gattuso.
Ancelotti said afterwards that he was due to meet club owner and president De Laurentiis Wednesday.
"We agreed to have a meeting," he said.
"I hope to stay but that is a decision the president will make. This team has quality which they have shown in the Champions League but not in the league.
"They haven't said anything to me, I was just preparing the match. Will I resign? I've never done that in my life."
The downbeat mood was apparent from the start when the host were greeted by a lukewarm reception, with the San Paolo stadium less than one quarter full.
Former Chelsea, Real Madrid and Bayer Munich coach Ancelotti led Napoli to second place in Serie A last season but his team have suffered a loss of form this term and they fell out with De Laurentiis after he ordered the players to be confined to a week-long training camp.