• Monday, Dec 06, 2021
  • Last Update : 11:29 pm

Research: Plasma therapy ineffective in reducing Covid-19 death

  • Published at 02:13 pm September 10th, 2020
Blood plasma
File photo: An apheresis machine separates and collects convalescent plasma from the whole blood of a recovered coronavirus patient at the Central Seattle Donor Center of Bloodworks Northwest during the outbreak in Seattle on April 17, 2020 Reuters

The Indian Council of Medical Research made these revelations after conducting a study in 39 hospitals across India

The Indian Council of Medical Research (ICMR) has said that Convalescent Plasma (CP) therapy does not help in reducing deaths resulting from Covid-19.

"CP was not associated with reduction in mortality or progression to severe Covid-19," said the study, published in Medrxiv, a pre-print server for health sciences, reports UNB citing Xinhua.

However, the study has not been peer-reviewed yet.

The top medical research body has made these revelations on the effectiveness of plasma therapy for the treatment of Covid-19 after conducting a study in 39 hospitals across India.

For this, the ICMR researchers did an open-label, parallel-arm, phase II, multicenter, and randomized controlled trial from April 22 to July 14 this year. The trial was registered with the Clinical Trial Registry of India (CTRI) for the purpose, it said.

For the study 1,210 patients (moderately ill, confirmed Covid-19 cases) admitted across 39 trial sites were screened.


Also Read- Plasma therapy not always the answer against Covid-19


The participants were divided into two groups - the intervention arm of 235 participants received two doses of plasma at a 24-hour interval, while the control arm with 229 participants received "best standard of care" (BSC) without plasma. All participants were hospitalized with moderate disease.

The primary outcome was measured on the basis of progression to severe disease or possible death, 28 days after enrolment.

Mortality among participants in the intervention and control arms was 13.6% and 14.6%, respectively. In both categories, the disease progressed to severe illness in 7.2% of the patients in the intervention arm and 7.4% of the patients in the control arm.

"The PLACID trial results indicate that there was no difference in 28-day mortality or progression to severe disease among moderately ill Covid-19 patients treated with CP along with BSC (best standard of care) compared to BSC alone," the report said.

Convalescent plasma therapy for Covid-19 involves the transfusion of a recovered patient's plasma into someone whose body has not been able to mount a strong enough response against the disease. The idea behind plasma therapy is to leverage the antibodies in a recovered patient's plasma to help others beat the disease.

ICMR has previously stated there was no robust evidence to support plasma therapy as Covid-19 treatment.


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