Israel pounded south and central Gaza on Friday as Egypt was to host a high-level Hamas delegation for talks to try and end the nearly 12-week war that has devastated the besieged Palestinian territory.
The Israeli military said its forces are extending operations in Khan Yunis" over the past 24 hours.
AFPTV footage showed smoke billowing over Rafah, near Egypt, following fresh strikes on Friday, reports AFP.
Israeli shelling near Al-Amal in Khan Yunis killed 41 people over the past two days, the Palestinian Red Crescent Society said on Thursday.
The casualties in repeated Israeli strikes near the facility include "displaced persons seeking shelter", it said.
The UN humanitarian office said an estimated 100,000 more displaced people had arrived in the already-teeming southern border city of Rafah in recent days following the intensification of fighting around Deir al-Balah and Khan Yunis.
At Al-Aqsa Hospital in Deir al-Balah, Palestinians gathered to identify loved ones killed in strikes.
The fighting left much of Gaza's north in ruins, while the battlefront has shifted ever further to the south and raised tensions across the Middle East.
Israel's relentless aerial bombardment and ground invasion in Gaza have killed at least 21,507 people, mostly women and children, according to the health ministry in Gaza.
The figure includes 187 fatalities over the past 24 hours, a ministry statement said. The Israeli army says 168 of its soldiers have been killed inside Gaza.
Sources close to Hamas said Egypt's three-stage plan provides for renewable ceasefires, a staggered release of hostages in exchange for Palestinian prisoners in Israel, and ultimately an end to the war.
Hamas's military wing, Ezzedine al-Qassam Brigades, said it launched a fresh barrage of rockets at southern Israel on Friday.
Rows of white shrouds
"My life, my eyes, my soul," a husband writes on the white shroud wrapped around his wife after the war devastating Gaza took her life.
A bereaved son writes "my mother and everything" on the burial cloth covering his mother, another of the more than 21,000 Palestinians killed in the Israel-Hamas confrontation.
While the besieged Palestinian territory faces severe shortages of food, water and medicine, the white coverings used to wrap dead Palestinians have remained in abundant supply, reports Reuters.
However, not all the shrouds bear loving words. Some of them bear the words "unknown male" or "unknown female", and before burial pictures are taken and the date and place of the strike documented so individuals can be identified by relatives later.