Carried by a wave of raw emotion, leaders Liverpool will look to land a potentially decisive blow in the Premier League title race when they host Manchester City on Sunday.
Tributes to mark the 25th anniversary of the Hillsborough disaster will frame the encounter and with Liverpool on course for a first title since 1990, Anfield is likely to be a cauldron of fervour and belief.
As with every other game in England this weekend, kick-off will occur seven minutes later than scheduled as a mark of respect for the 96 Liverpool fans who died after a fatal crush at Sheffield Wednesday's Hillsborough stadium during an FA Cup semi-final in 1989.
The timing reflects the moment at which that game against Nottingham Forest was called to a halt.
Former players from the two sides will exchange wreaths prior to the match, which will also be preceded by a rendition of the Liverpool anthem, 'You'll Never Walk Alone', and a minute's silence.
Fresh inquests into the deaths opened recently after the original coroner's verdicts of accidental death were quashed following a campaign by victims' families, whose wounds remain as fresh as ever.
While no amount of on-pitch success will ever provide adequate consolation, Liverpool manager Brendan Rodgers says that his side's title bid is inspired by memories of the Hillsborough dead.
"We can't say too much about Hillsborough because the inquests are under way," he said earlier this week.
"But as a manager coming into the football club, I know there are 96 people in the sky who will always be supporting this football team.
"If we are to achieve anything this year, they will always be in our thoughts -- the 96 in the sky and the families that go with them."
- Aguero boost for City -
The rawness of the occasion leaves City in an uncomfortable position, and manager Manuel Pellegrini has encouraged his players to approach the game with clear heads.
"It will be a very emotional day, but the team that has the cold mind will win the game," said the Chilean.
"It is easy in these big games to have the motivation, but it is very important to manage the anxiety. That is very important for all the players."
Pellegrini has also claimed that it is "not a game that will decide the title", but a win for either side would alter the picture significantly, as both sides know that they will be champions if they win all of their remaining matches.
City, who trail Liverpool by four points with two games in hand, received a huge fillip prior to the game with the news that top scorer Sergio Aguero will be fit to play after five games out with a hamstring problem.
Apart from centre-back Matija Nastasic, who has an ongoing knee complaint, Pellegrini has a fully fit squad to select from, while left-back Jose Enrique (also knee) will be the only absentee for the home side.
With 29 goals to his name, Liverpool striker Luis Suarez needs just two more goals to equal the Premier League scoring record for a 38-game season, but he says that the team's requirements come first.
"Of course it would be special," said the Uruguayan.
"But for myself, it is more important that Liverpool finish in a good position. I try in every game to score because I am a striker."
Back-to-back defeats at City and Chelsea left Liverpool six points below leaders Arsenal at the turn of the year, but a burst of nine consecutive wins (during which they have plundered 32 goals) has propelled them to the summit.
City have an impressive record against Liverpool in recent seasons, however, having avoided defeat in their last five league encounters.
Rodgers can nonetheless take heart from the fact that his side have won all four of their home meetings against the other teams in the top seven so far this season, scoring 14 times and conceding only once.
Chelsea's looming Champions League semi-final with Atletico Madrid will be put to one side as Jose Mourinho's side attempt to strengthen their Premier League title challenge at Swansea.
The Stamford Bridge club will head to South Wales on Sunday having been boosted by this week's memorable victory over Paris Saint-Germain that took them one step closer towards clinching European football's top prize for the second time in three years.
And they could receive a further lift immediately before kick-off when the outcome of Manchester City's trip to Liverpool is known.
Chelsea head into the latest round of matches in second place, two points behind leaders Liverpool and two points ahead of third-placed Manchester City, who have two games in hand.
With Liverpool playing Manchester City earlier on Sunday, a situation that could lead to at least one of Chelsea's title rivals dropping points, Jose Mourinho's side will look to take advantage at the Liberty Stadium.
Confidence is high after the way they overturned a two-goal deficit against PSG. But Chelsea's recent problems away from home ensure three points certainly cannot be taken for granted by the London club.
- 'Forward power' -
The Blues have lost their last three away matches, against Premier League strugglers Aston Villa and Crystal Palace before the 3-1 first leg defeat in the Parc des Princes. A return of one goal in those three games underlined why Mourinho remains concerned about his side's lack of forward power, despite following last weekend's 3-0 home win against Stoke with the 2-0 victory over PSG.
Once again the manager must decide which of his three forwards will get the nod to lead the line with Samuel Eto'o the favourite to start.
Demba Ba -- scorer of the 87th minute goal that settled Tuesday's tie -- and Fernando Torres will most likely again be on the bench.
Nemanja Matic and Mohamed Salah are expected to be restored to the starting line-up after being ineligible to face PSG while Ramires also returns following a three-game domestic ban.
Angel Rangel is confident Swansea's home form will ensure they quickly confirm their Premier League status for another season.
The Welsh club are six points above the relegation zone before facing Chelsea on Sunday. After taking on the Blues, Swansea, who beat Norwich in their last home fixture, also have Aston Villa and Southampton to play at the Liberty before the end of the campaign.
And Spanish right-back Rangel feels those matches will determine which direction their struggling season will go.
"We know we are not safe," he said. "We have five games left, three at home and two away. We have 15 points left to play for and we don't want to rely on other teams losing, we want to win.
"We can win games, especially down the Liberty, where we've got three left against Aston Villa and Southampton. I know we have Chelsea next, which is going to be a tough one, but we've got a chance.
"When teams around us play each other we know someone is going to get points -- that's obvious. We have a gap above the relegation zone, it's not a lot, and we have to work hard until the end of the season.
"It's going to be vital to get some points at the Liberty. Those games are going to be very important."