Holders Manchester United will face their former striker Ruud van Nistelrooy's Leicester City at Old Trafford in the FA Cup fourth round.
Van Nistelrooy worked as Erik ten Hag's assistant at United from the start of this season and then served as interim boss following the Dutchman's sacking.
He left Old Trafford after Ruben Amorim's arrival as Ten Hag's permanent replacement and subsequently took charge at Leicester.
Van Nistelrooy, who scored in United's 2004 FA Cup final win against Millwall, is fighting to lift Leicester out of the Premier League relegation zone.
The 48-year old spent five years as a United player before joining Real Madrid in 2006.
United, who had Diogo Dalot sent off in the second half, advanced to the fourth round after beating Arsenal 5-3 on penalties following their 1-1 draw Sunday.
Premier League leaders Liverpool - 4-0 winners against Accrington Stanley - will travel to the Championship's bottom club Plymouth, who enjoyed a shock 1-0 win at Brentford.
Manchester City face a trip to either Leyton Orient or Derby County, while Chelsea visit Brighton and Hove Albion, Aston Villa host Tottenham Hotspur and Everton take on Bournemouth.
Exeter, in the fourth round for the first time since 1981, face Nottingham Forest and Newcastle United will play at League One leaders Birmingham City.
Premier League sides Wolverhampton Wanderers, Crystal Palace and Fulham have away ties at Blackburn Rovers, Mansfield or Wigan Athletic and Doncaster Rovers, respectively.
Burnley have been drawn at Premier League strugglers Southampton.
FA Cup 4th round draw:
Man Utd v Leicester
Leeds v Millwall or Dagenham
Brighton v Chelsea
Preston or Charlton v Wycombe
Exeter v Forest
Coventry v Ipswich
Blackburn v Wolves
Mansfield or Wigan v Fulham
Birmingham v Newcastle
Plymouth v Liverpool
Everton v Bournemouth
Villa v Tottenham
Southampton v Burnley
Leyton or Derby v Man City
Doncaster v Palace
Stoke v Cardiff
- Ties to be played from February 7-10