Bangladesh have to score 170 runs to win the second Twenty20 international of two-match series against South Africa at the Sher-e-Bangla National Stadium in Dhaka.
South Africa scored 169 runs in 20 overs losing four wickets.
South Africa captain Faf du Plessis won the toss and elected to bat first.
The match began at 1pm on Tuesday.
South Africa made one change to their XI. Legspinner Eddie Leie made his international debut, replacing fast bowler Kagiso Rabada. Leie had taken 1 for 11 in the warm-up T20 in Fatullah.
Bangladesh also had a debutant in Rony Talukdar, who was listed to bat at No 8. He replaced Sohag Gazi, who bowled two wicketless overs in his international comeback in the first T20I against South Africa.
The Proteas beat Tigers by 52-run in the first game held at the same venue on Sunday.
Bangladesh Team
Tamim Iqbal, Soumya Sarkar, Shakib Al Hasan, Mushfiqur Rahim†, Sabbir Rahman, Litton Das, Nasir Hossain, Rony Talukdar, Mashrafe Mortaza*, Arafat Sunny, Mustafizur Rahman
South Africa Team
Q de Kock†, AB de Villiers, F du Plessis*, JP Duminy, DA Miller, RR Rossouw, D Wiese, WD Parnell, AM Phangiso, KJ Abbott, E Leie