After losing four wickets, visiting South Africa scored 148 runs in the first T20 match of two-match series against Bangladesh in Sher-E-Bangla National Stadium in the capital's Mirpur.
South Africa captain Faf du Plessis scored 79 runs to help steady their innings.
Arafat Sunny picked up two wickets while Shakib al Hasan and Nasir Hossain claimed one each.
Earlier, South Africa won the toss and decided to bat. The match began at 1pm on Sunday.
Bangladesh Team
Tamim Iqbal, Litton Das†, Soumya Sarkar, Shakib Al Hasan, Mushfiqur Rahim, Sabbir Rahman, Nasir Hossain, Sohag Gazi, Mashrafe Mortaza*, Mustafizur Rahman, Arafat Sunny
South Africa Team
Q de Kock†, RR Rossouw, AB de Villiers, F du Plessis*, DA Miller, JP Duminy, D Wiese, WD Parnell, KJ Abbott, AM Phangiso, K Rabada